New research indicates that people who stop using new weight-loss injections like Mounjaro or Wegovy can put back on lost weight much more quickly than those who stop traditional diet and exercise programs.
Published data in a prominent health publication points out that while overweight individuals often shed substantial amounts of their body weight while undergoing treatment, the weight is regained at an average rate of nearly a kilo each month upon discontinuation.
"Users using such drugs must be cognizant of the potential of fast weight regain when the medication is stopped," stated researcher Dr. Susan Jebb.
This pace of regain means a return to starting weight within about 18 months.
Analyzing Treatments
The research, which examined dozens of trials involving over 9,000 of patients, contrasted the results of the injectable medications with older methods.
Researchers note that people who lose weight through lifestyle changes alone typically have a slower creep back—around 100 grams monthly—post-intervention.
Explaining the Quick Regain
Experts propose the way of the jabs is key to understanding the accelerated weight return.
The injections copy a body's own chemical called GLP-1, which moderates hunger.
"Sustained high doses of GLP-1 concentrations far above than normal could lead to the system to generate a reduced amount of its own natural hormone, and could reduce sensitivity to its actions," said Dr. Adam Collins, a nutrition expert.
"Stopping of this medication leads to appetite is uncontrolled, making excessive eating far more likely."
A Chronic Disease?
Medical guidelines advise the injections for individuals with obesity-related health risks, accompanied by prescribed diet and exercise modifications.
Many experts argue that, due to the high risk of relapse, the treatment might need to be long-term.
This opinion is echoed by pharmaceutical companies, who note that the results "highlight the long-term nature of obesity," akin to managing conditions like high blood pressure.
User Testimonies
Users who have discontinued the jabs report a sudden return of hunger.
"It was like a switch that goes on and I was suddenly extremely hungry," described an individual.
The struggle is compounded if patients have not developed lasting lifestyle or habit modifications during treatment.
Widespread Adoption
Figures show that millions of people in the UK have tried these injections in the last 12 months, with demand being substantial.
- Use is greater among women compared to males.
- The 40s and 50s age group shows the greatest level of interest.
- A large proportion access the medications through private prescriptions rather than public health services.
In conclusion, clinicians caution that while these medications are effective agents for weight loss, they are not a permanent cure and lasting health benefits hinges on integrated behavioural support.
